Former Graduate Students
Michelle Oppenheimer, Graduate Student
BS Chemistry, University of North Carolina, Chapel Hill, NC
Hometown: Charlotte, North Carolina Honors: American Heart Association Predoctoral Fellowship, 2010-2012 Johnson Memorial Scholarship for Outstanding Graduate Student, 2011 Virginia Tech Graduate Student Association Travel Fund Program Scholarship, 2010-2011 James F. Eheart Travel Scholarship, 2008-2011 Projects: Mechanistic studies of UDP-galactopyranose mutases. 2) Determination of the site of covalent attachment in tetrahydrofuran monooxygenase reductase, thmD. Period: Fall 2007- Spring 2012 Degree: PhD in Biochemistry Current Position: Instructor, Department of Chemistry, Mary Washington University, VA. Publications: 1) Oppenheimer, M., et al (2010) Recombinant expression, purification and characterization of ThmD, the oxidoreductase component of tetrahydrofuran monooxygenase. Archives of Biochemistry and Biophysics. 496.123-31. 2) Oppenheimer, M., et al. (2010) Characterization of recombinant UDP-galactopyranose mutase from Aspergillus fumigatus. . Archives of Biochemistry and Biophysics. 502. 31–38. 3) Oppenheimer, M., Valenciano, A.L., Sobrado, P. (2011) Characterization of Leishmania major Virulence Factor UDP-Galactopyranose Mutase. Biophysical Biochemical Research Communications. 407. 552-6. 4) Oppenheimer, M., Valenciano, A.L., Sobrado, P. (2011) Biosynthesis of Galactofuranose Biosynthesis in kinetoplastids: Novel Therapeutics Targets for Treating Leishmaniasis and Chagas’ Disease. Enzyme Research. vol. 2011, Article ID 415976, 13 pages. 5) Qi, J., Oppenheimer, M., Sobrado, P. (2011) Fluorescence Polarization Binding Assay for Aspergillus fumigatus Virulence factor UDP-Galactopyranose Mutase. Enzyme Research. vol. 2011, Article ID 513905, 9 pages. 6) Dhatwalia, R., Singh, H., Oppenheimer, M., Karr, D.B., Nix, J.C., Sobrado, P., Tanner, J.J., (2012) Crystal structures and small-angle X-ray scattering analysis of UDP-galactopyranose mutase from the pathogenic fungus Aspergillus fumigatus, J. Biol. Chem. 286. 9041-51. 7) Oppenheimer, M., Valenciano, A.L., Kizjakina, K., Qi, J. Sobrado, P., (2012) Chemical Mechanism of UDP-Galactopyranose Mutase from Trypanosoma cruzi: a Potential Drug Target Against Chagas’ Disease, PLoS ONE. 7(3) e32918. 8) Dhatwalia, R., Singh, H., Oppenheimer, M., Sobrado, P., Tanner, J.J. (2012) Crystal Structures of Trypanosoma cruzi UDP-Galactopyranose Mutase Implicate Flexibility of the Histidine Loop in Enzyme Activation. Biochemistry. 51. 4968-79. 9) Dhatwalia, R., Singh, H., Solano, L.M., Oppenheimer, M., Robinson, R., Ellerbrock, J.E., Sobrado, P., Tanner, J.J. (2012) Identification of the NAD(P)H Binding Site of Eukaryotic UDP-Galactopyranose Mutase. J. Am. Chem. Soc. 134. 18132-8 10) Romero, E., Fedkenheuer, M., Chocklett, S.W., Qi, J., Oppenheimer, M., Sobrado, P., (2012). Dual role of NADP(H) in the reaction of a flavin dependent N-hydroxylating monooxygenase. Biochim. Biophys. Acta. 6. 850-7. |